|
T8642 |
4-CMTB
|
|
GPR
|
|
4-CMTB is a selective agonist of FFA2 and GPR43.It also is a positive allosteric modulator (pEC50=6.38). |
|
T7482 |
3-chloro-5-hydroxybenzoic Acid
|
|
GPR
|
|
3-chloro-5-hydroxy Benzoic Acid (3-chloro-5-hydroxy BA) is an agonist of GPR81 (EC50 : 16 μM) |
|
T7796 |
TUG-1375
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|
GPR
|
|
TUG-1375 is an Agonist of Thiazolidine Free Fatty Acid Receptor 2 |
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T15810 |
LY2922470
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|
GPR
|
|
LY2922470 reduces glucose levels along with significant enhancements in insulin and GLP-1, which is the potential for the treatment of type 2 diabetes mellitus (T2DM). LY2922470 is an effective, selective, and orally ava... |
|
T4312 |
GPR120 Agonist 2
|
GPR120 receptor agonist |
GPR
|
|
GPR120 Agonist 2 is a potent and selective GPR120 receptor agonist. |
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T11458 |
GPR40/FFAR1 modulator 1
|
|
GPR
|
|
GPR40/FFAR1 modulator 1 is a Gq-coupled free fatty acid receptor 1 (GPR40/FFAR1) agonist and allosteric modulator. |
|
T3433 |
TUG-891
|
TUG 891,TUG891 |
GPR
|
|
TUG-891 is a G protein-coupled receptor (GPCR) expressed in intestine, adipocytes, and pro-inflammatory macrophages that is activated by long chain free fatty acids. |
|
T2351 |
Fasiglifam
|
TAK875 |
GPR
|
|
Fasiglifam (TAK875) is a potent, selective and orally bioavailable GPR40 agonist. |
|
T22027 |
AH-7614
|
AH 7614 |
GPR
|
|
AH-7614 (AH 7614) is a selective and potent free fatty acid receptor 4 (FFA4/GPR120) antagonist. |
|
TQ0020 |
AMG 837 calcium hydrate
|
|
GPR
|
|
AMG 837 calcium hydrate is a potent GPR40 agonist with an EC50 of 13 nM. AMG 837 calcium hydrate also shows highly selective over GPR41, GPR43, and GPR120 (EC50 > 10,000 nM). |
|
T7127 |
DC260126
|
|
Apoptosis
,
GPR
|
|
DC260126 is a small-molecule antagonist of FFA1 (GPR40) |
|
T15413 |
GPR120 Agonist 3
|
GPR120-IN-1 |
GPR
|
|
GPR120 Agonist 3 (GPR120-IN-1) is a selective agonist of Gpr120 ( logEC50: -7.62). |
|
T22967 |
MEDICA16
|
MEDICA 16 |
GPR
,
Others
,
ATP Citrate Lyase
|
|
Free fatty acid 1 (FFA1/GPR40) receptor agonist |
|
T3171 |
GSK137647A
|
GSK 137647 |
GPR
|
|
GSK137647A (GSK 137647) is a selective FFA4 agonist. |
|
T12883 |
Fezagepras
|
PBI-4050,Setogepram |
GPR
|
|
Fezagepras (Setogepram) is an orally active GPR40 agonist and is an antagonist or inverse agonist of GPR84 with anti-inflammatory, anti-fibrotic, and anti-proliferative actions. |
|
T1781 |
GW9508
|
GW 9508 |
GPR
,
Potassium Channel
|
|
GW9508(GW 9508) is a potent and selective agonist for FFA1 (GPR40), stimulates insulin secretion in a glucose-sensitive manner. |
|
T9437 |
1-methoxycyclopropanecarboxylic acid
|
|
GPR
|
|
1-methoxycyclopropanecarboxylic acid is an agonist of free fatty acid receptor 3 (FFAR3, human). |
|
T34967 |
TUG-469
|
TUG469,TUG 469 |
GPR
|
|
TUG-469 is an agonist of free fatty acid 1(FFA) receptor. |
|
T17177 |
TUG-424
|
TUG424 |
Others
|
|
TUG-424 significantly enhances glucose-stimulated insulin secretion at 100 nM. TUG-424 is a potent and selective free fatty acid receptor 1 agonist (EC50: 32 nM). |
|
T60184 |
TUG-499
|
|
GPR
,
PPAR
|
|
TUG-499 is a selective free fatty acid receptor 1 (FFAR1 or GPR40) agonist (EC50: 7.39).TUG-499 has an affinity for FFAR1 or GPR40 over the related receptors FFA2, FFA3 and the nuclear receptor PPARγ, as well as other di... |
|
TP1930L1 |
Spexin acetate(1370290-58-6 free base)
|
|
Neuropeptide Y Receptor
|
|
Spexin acetate is a potent galanin receptor 2/3 (GAL2/GAL3) agonist (EC50 values are 45.7 and 112.2 nM, respectively). Exhibits no significant activity at galanin receptor 1. Endogenous satiety-inducing peptide; inhibits... |
|
TQ0241 |
TUG-770
|
|
GPR
|
|
TUG-770 is a highly potent agonist of free fatty acid receptor 1 (FFA1/GPR40, EC50: 6 nM for hFFA1). |
|
T34968 |
TUG-905
|
|
|
|
TUG-905 is an agonist for free fatty acid receptor 4 (FFA4/GPR120), and TUG-905 has the potential to treat agitation. |
|
T15267 |
GPR40 agonist 4
|
|
Others
|
|
GPR40 agonist 4 is a potent free fatty acid agonist of receptor 1 (pEC50: 7.54). |
|
T25508 |
HUHS2002
|
HUHS 2002,HUHS-2002 |
|
|
HUHS2002 is a free fatty acid derivative that works as a potentiator of GluA1 AMPA receptor responses and α7 ACh receptor responses. |
|
T11583 |
HWL-088
|
|
Others
|
|
HWL-088 is a potent free fatty acid receptor 1 (FFA1/GPR40) agonist. HWL-088 significantly improves glucose tolerance in normal and diabetic models. |
|
T26935 |
C108297
|
C-108297,C 108297 |
|
|
C108297 is a glucocorticoid receptor modulator. C108297 prevents both diet-induced obesity and inflammation. C108297 decreased food and fructose intake and increased lipolysis in white adipose tissue (WAT) and free fatty... |
|
T70468 |
MK-8666
|
|
|
|
MK-8666 is a partial GPCR (G-protein-coupled receptor) agonist that is coordinated with the action of GPR40. GPR40, also known as free fatty acid (FFA) receptor 1 modulates fatty acid-induced insulin secretion in pancrea... |
|
T27228 |
E-3030 free acid
|
E-3030,E3030,E 3030 |
|
|
E-3030 free acid is a peroxisome proliferator-activated receptor (PPAR) agonist. E-3030 decreased blood glucose, triglyceride, non-esterified fatty acids, and insulin levels and increased blood adiponectin levels. Trigly... |
|
T36634 |
ZQ 16
|
|
|
|
Selective medium-chain free fatty acid receptor GPR84 agonist (EC50 = 139 nM). Exhibits no response at GPR40, GPR41, GPR119 or GPR120 at 100 μM. Activates calcium mobilization, inhibits cAMP accumulation, and induces ERK... |
|
T69953 |
MK-8666 Tris
|
|
|
|
MK-8666 Tris is a partial GPCR (G-protein-coupled receptor) agonist that is coordinated with the action of GPR40. GPR40, also known as free fatty acid (FFA) receptor 1 modulates fatty acid-induced insulin secretion in pa... |
|
T61055 |
GPR40 agonist 6
|
|
|
|
GPR40 agonist 6 (Compound 7a) is a potent and selective agonist of free fatty acid receptor 1 ( FFAR1 or GPR40 ) with an EC 50 of 0.058 μM against GPR40 [1]. |
|
T38070 |
Arachidonic Acid-biotin
|
|
|
|
Virtually all cellular arachidonic acid is esterified in membrane phospholipids where its presence is tightly regulated through multiple interconnected pathways. Free arachidonic acid is a transient, critical substrate f... |
|
T71663 |
FFA3 agonist 1
|
|
|
|
FFA3 Agonist 1, a potent agonist of the free fatty acid receptor 3 (FFA3), plays a crucial role in mediating the health-promoting effects of the intestinal microbiota through the activation of FFA3. |
|
T69824 |
PSB-17365
|
|
|
|
PSB-17365 is a potent GPR84 agonist. PSB-17365 exhibits EC50 values vs. GPR84 of 2.5nM in a cAMP accumulation assay, and 100nM in a β-arrestin 2 recruitment assay. No direct binding affinities are provided. PSB-17365 is ... |
|
T35791 |
Palmitic acid-13C
|
|
|
|
Palmitic acid-13C is intended for use as an internal standard for the quantification of palmitic acid by GC- or LC-MS. Palmitic acid-13C contains 13C at the C2 position and has been used in the study of free fatty acid i... |
|
T37896 |
AZ 1729
|
|
|
|
FFA2 allosteric agonist. Inhibits forskolin-induced cAMP increase and stimulates 35SGTPγS binding in biochemical assays (pEC50 values are 6.9 and 7.23, respectively). Binds at allosteric binding site. In functional assay... |
|
T35816 |
ZLY032
|
|
|
|
ZLY032 is a dual agonist of free fatty acid receptor 1 (FFAR1/GPR40; EC50= 68 nM in a FLIPR assay) and peroxisome proliferator-activated receptor δ (PPARδ; EC50= 102 nM in a reporter assay).1It is selective for FFAR1 and... |
|
T83955 |
MOMBA
|
|
|
|
MOMBA is a selective orthosteric agonist specifically targeting engineered human free fatty acid 2 (hFFA2) receptors, particularly those modified as designer receptors activated by designer drugs (DREADD). It demonstrate... |
